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AUGUST 2008
 
Green Vaccines
 

 
 
Green Vaccines
Proc. Natl Acad.
Sci. USA 105, 10131?10136 (2008)


Ronald Levy of Stanford University Medical Center in California and his colleagues have carried out the first clinical trial of plant produced therapeutic vaccines against non- Hodgkin’s lymphoma. The vaccines were grown in tobacco plants by infecting the plants with a tobacco mosaic virus containing
DNA fragments cloned from each patient’s cancer cells, thus matching each vaccine to its potential beneficiary. Eleven of the 16 participants with the cancer had developed a cellular immune response 28 days after vaccination; six of these made antibodies specific to certain proteins found on the surface of their cancerous white blood cells.

 
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