Genetically Modified Peanuts Could Save Lives

- Aaron Rowe, Wired, November 30, 2008

Genetically engineered peanuts may help fight the most common cause of fatal allergic reactions to food in the United States. While the research is unlikely to result in the creation of completely allergen-free peanuts, it could result in fewer outbreaks and even fewer deaths.

For years now, government scientists have been testing ordinary peanuts in the hope of finding one that cannot cause the deadly allergic reactions which kill more than 50 Americans every year. But nature may not be able to provide an answer.

Horticulture expert Peggy Ozias-Akins at the University of Georgia in Tifton is taking a different tack by using genetic engineering to grow hypoallergenic peanuts.

Most allergic reactions to peanuts are triggered by the same eleven molecules. In theory, peanuts without the genes responsible for those molecules would be far less likely to trigger allergic reactions. "Some proteins cause more severe allergic reactions than others," said Ozias-Akins.

Tackling the worst offenders first, her team has made and tested peanuts that do not produce two proteins that are among the most intense allergens. The research appears in The Journal of Agricultural and Food Chemistry.
http://pubs.acs.org/doi/abs/10.1021/jf802600r

The biologists shot a customized DNA sequence into the plants with a gene gun, causing the legumes to produce hairpin-shaped RNA molecules, which halt the production of the two proteins. Messing with the genetic code of a plant could potentially cause the seeds to develop improperly, change the taste of the crop, or render it more susceptible to fungal infections. But Ozias-Akins' team found that they grow normally and can resist a common mold without any problems.

Still, getting rid of every allergy-causing substance in peanuts would not be easy, Ozias-Akins said. "Given the number of allergenic proteins in peanuts, I doubt that developing an allergen-free peanut is realistic." Although it may be impossible to make a perfectly safe peanut, clipping the right genes out could make food accidents far less common.