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p569 | doi:10.1038/nrg2426
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Small RNAs: Roundworm joins the piRNA club
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Epigenetics: Getting to the roots of mammalian imprinting
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Human disease: Keeping risk in the family
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Comparative genomics: Lining up is hard to do
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The environmental contribution to gene expression profiles
Greg Gibson
p575 | doi:10.1038/nrg2383
It is now feasible to dissect the influence of the environment on gene function in many species - a desirable goal from a biomedical, agricultural and evolutionary perspective. This article describes the progress made so far, and the analytical challenges to be overcome.
Abstract
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REVIEWS
Tuning gene expression to changing environments: from rapid responses to evolutionary adaptation
Luis López-Maury, Samuel Marguerat & Jürg Bähler
p583 | doi:10.1038/nrg2398
In contrast to growth control, gene expression responses to stress involve distinctive regulatory mechanisms that are characterized by high levels of noise. These features allow organisms to respond quickly to unpredictable environmental changes, and recent studies suggest that they also promote the evolvability of gene regulation.
Abstract
<http://ealerts.nature.com/cgi-bin24/DM/y/hmN30aNjgP0Hjc0Bz1u0Ei>
| Full Text <http://ealerts.nature.com/cgi-bin24/DM/y/hmN30aNjgP0Hjc0Bz180Eh>
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DNA polymerases and human disease
Lawrence A. Loeb & Raymond J. Monnat, Jr
p594 | doi:10.1038/nrg2345
There are now 14 DNA polymerases in the human genome. This article explores the function of these molecules in replicating DNA, their regulation and involvement in disease, and how specific properties of each polymerase might be targeted for therapeutic ends.
Abstract
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Horizontal gene transfer in eukaryotic evolution
Patrick J. Keeling & Jeffrey D. Palmer
p605 | doi:10.1038/nrg2386
It is well known that prokaryotes regularly exchange genes by horizontal transfer, but there is increasing evidence that such processes also have an important role in eukaryotic evolution, although the extent of this differs widely between lineages.
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Single-strand break repair and genetic disease
Keith W. Caldecott
p619 | doi:10.1038/nrg2380
Single-strand breaks are the most common type of DNA damage that arise in cells. Keith Caldecott discusses the molecular mechanisms and organization of the pathways that repair these lesions and the link between defects in these pathways and hereditary neurodegenerative disease.
Abstract
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The genetics of vertebrate myogenesis
Robert J. Bryson-Richardson & Peter D. Currie
p632 | doi:10.1038/nrg2369
Studies in the chick, mouse, zebrafish and other vertebrate model systems are beginning to uncover the complexities of skeletal muscle development. Distinct sets of precursor cells and various different gene regulatory networks are responsible for the spatial and temporal heterogeneity of the process.
Abstract
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